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KMID : 1145520160020010017
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Journal of Radiopharmaceuticals and Molecular Probes
2016 Volume.2 No. 1 p.17 ~ p.21
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Development of diverse fluorides source for applicable F-18 radiofluorination method
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Park Su-Hong
Kim Dong-Wook
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Abstract
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Alkali metal fluoride sources (MFs) such as potassium fluoride (KF) have been widely used as a fluoride source in the nucleophilic displacement reaction. However, they have low solubility and nucleophilicity in most of the organic solvents. Bulky fluoride sources such as tetrabutylammonium fluoride (TBAF) were substituted for MFs to improve these properties. However, hygroscopic property of TBAF makes it less convenient for handling as well as its strong basic property can make the side-reaction occur. Recently, novel fluoride sources have been developed to solve these problems. In this paper, we would like to introduce coordinated fluoride sources as a new fluoride sources such as tetrabutylammonium tetra(t-butyl alcohol)-coordinated fluoride, crown ether metal complex fluoride, and various bulky alcohols coordinated fluoride complexes. In particular, bulky alcohol coordinated fluoride source could generated by the controlled hydrogen-bonded of fluoride with alcohols and these fluoride sources have better stability and reactivity with showing low hygroscopic property. The study of these fluoride sources will help to understand the characteristic of [18F]fluoride for increasing the radiochemical yield in the [18F]radiofluorination.
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KEYWORD
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Nucleophilic fluorination, Fluoride source, Flexible fluoride, [18F]fluoride, t-alcohol media, phase transfer catalysts
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